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Original Article
- Associations of Serum Ferritin and Transferrin % Saturation With All-cause, Cancer, and Cardiovascular Disease Mortality: Third National Health and Nutrition Examination Survey Follow-up Study
- Ki-Su Kim, Hye-Gyeong Son, Nam-Soo Hong, Duk-Hee Lee
- J Prev Med Public Health. 2012;45(3):196-203. Published online May 31, 2012
- DOI: https://doi.org/10.3961/jpmph.2012.45.3.196
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Abstract
PDF Objectives Even though experimental studies have suggested that iron can be involved in generating oxidative stress, epidemiologic studies on the association of markers of body iron stores with cardiovascular disease or cancer remain controversial. This study was performed to examine the association of serum ferritin and transferrin saturation (%TS) with all-cause, cancer, and cardiovascular mortality.
Methods The study subjects were men aged 50 years or older and postmenopausal women of the Third National Health and Nutrition Examination Survey 1988-1994. Participants were followed-up for mortality through December 31, 2006.
Results Serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality for either men or postmenopausal women. However, all-cause, cancer, and cardiovascular mortality were inversely associated with %TS in men. Compared with men in the lowest quintile, adjusted hazard ratios for all-cause, cancer, and cardiovascular mortality were 0.85, 0.86, 0.76, and 0.74 (
p for trend < 0.01), 0.82, 0.73, 0.75, and 0.63 (p for trend < 0.01), and 0.86, 0.81, 0.72, and 0.76 (p for trend < 0.01), respectively. For postmenopausal women, inverse associations were also observed for all-cause and cardiovascular mortality, but cancer mortality showed the significantly lower mortality only in the 2nd quintile of %TS compared with that of the 1st quintile.Conclusions Unlike speculation on the role of iron from experimental studies, %TS was inversely associated with all-cause, cancer and cardiovascular mortality in men and postmenopausal women. On the other hand, serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality.
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Citations
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Circulation Journal.2024; 88(5): 742. CrossRef - Iron Metabolic Biomarkers and the Mortality Risk in the General Population: A Nationwide Population-Based Cohort Study
Yuanyuan Sun, Wenyao Peng, Siqi Lin, Jingjing Cui, Jiapeng Lu
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Trends in Endocrinology & Metabolism.2023; 34(7): 404. CrossRef - Transferrin predicts trimethylamine-N-oxide levels and is a potential biomarker of cardiovascular disease
Lamuel D. Bean, Jeffrey J. Wing, Randall E. Harris, Suzanne M. Smart, Subha V. Raman, M. Wesley Milks
BMC Cardiovascular Disorders.2022;[Epub] CrossRef - Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models
Leonardo dos Santos, Sabrina Rodrigues Bertoli, Renata Andrade Ávila, Vinícius Bermond Marques
Biochimica et Biophysica Acta (BBA) - General Subjects.2022; 1866(9): 130172. CrossRef - Association of ferritin and transferrin saturation with all-cause mortality, and the effect of concurrent inflammation: a danish cohort study
Nikki H. Mitchell, Henrik L. Jørgensen, Fie J. Vojdeman, Henriette P. Sennels, Christen L. Andersen, Margit Kriegbaum, Mia K. Grand, Christine W. Bang, Bent S. Lind
Scandinavian Journal of Clinical and Laboratory Investigation.2022; 82(7-8): 525. CrossRef - Iron Restriction Alleviates Atherosclerosis in ApoE KO Mice: An iTRAQ Proteomic Analysis
Gang Luo, Lu Xiang, Lin Xiao
International Journal of Molecular Sciences.2022; 23(24): 15915. CrossRef - Nano‐sensing and nano‐therapy targeting central players in iron homeostasis
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WIREs Nanomedicine and Nanobiotechnology.2021;[Epub] CrossRef - Dietary iron overload mitigates atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice: Role of dysregulated hepatic fatty acid metabolism
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(10): 159004. CrossRef - The role of hepcidin and iron homeostasis in atherosclerosis
Florian Wunderer, Lisa Traeger, Haakon H. Sigurslid, Patrick Meybohm, Donald B. Bloch, Rajeev Malhotra
Pharmacological Research.2020; 153: 104664. CrossRef - Iron loading, alcohol and mortality: A prospective study
Rudolph Schutte, Hugo Huisman, Catharina M.C. Mels, Shani Botha, Ruan Kruger, Wayne Smith, Iolanthé M. Kruger, Michelle Hawkins, Lee Smith, Yolandi Breet, Aletta E. Schutte
Clinical Nutrition.2019; 38(3): 1262. CrossRef - Prognostic implications of low transferrin saturation in patients with primary myelofibrosis
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Leukemia Research.2018; 66: 89. CrossRef - Iron status in relation to cancer risk and mortality: Findings from a population‐based prospective study
Daniel A. Quintana Pacheco, Disorn Sookthai, Mirja E. Graf, Ruth Schübel, Theron Johnson, Verena A. Katzke, Rudolf Kaaks, Tilman Kühn
International Journal of Cancer.2018; 143(3): 561. CrossRef - Targeting iron metabolism in drug discovery and delivery
Bart J. Crielaard, Twan Lammers, Stefano Rivella
Nature Reviews Drug Discovery.2017; 16(6): 400. CrossRef - The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing
Nikolaos P. E. Kadoglou, Jane P. Biddulph, Snorri B. Rafnsson, Marialena Trivella, Petros Nihoyannopoulos, Panayotes Demakakos, Abelardo I Aguilera
PLOS ONE.2017; 12(6): e0178994. CrossRef - Management of iron overload in hemoglobinopathies: what is the appropriate target iron level?
Thomas D. Coates, Susan Carson, John C. Wood, Vasilios Berdoukas
Annals of the New York Academy of Sciences.2016; 1368(1): 95. CrossRef - Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status
Stephen T. McSorley, Iain Jones, Donald C. McMillan, Dinesh Talwar
Translational Research.2016; 176: 119. CrossRef - High serum levels of ferritin at baseline are not associated with an increased risk of mortality in oldest old community‐dwelling adults: The OCTABAIX study
Francesc Formiga, Assumpta Ferrer, Gloria Padros, Carme Gimenez‐Argente, Rosa López Pisa, Xavier Corbella
Geriatrics & Gerontology International.2016; 16(2): 284. CrossRef - Iron toxicity and its possible association with treatment of Cancer: Lessons from hemoglobinopathies and rare, transfusion-dependent anemias
Mammen Puliyel, Arch G Mainous, Vasilios Berdoukas, Thomas D Coates
Free Radical Biology and Medicine.2015; 79: 343. CrossRef - Parameters influencing in-hospital mortality in patients hospitalized in intensive cardiac care unit: is there an influence of anemia and iron deficiency?
Ewa Uscinska, Bozena Sobkowicz, Robert Sawicki, Izabela Kiluk, Malgorzata Baranicz, Tomasz Stepek, Milena Dabrowska, Maciej Szmitkowski, Wlodzimierz J. Musial, Agnieszka M. Tycinska
Internal and Emergency Medicine.2015; 10(3): 337. CrossRef - Low transferrin saturation is associated with impaired fasting glucose and insulin resistance in the South Korean adults: the 2010 Korean National Health and Nutrition Examination Survey
R. J. Park, J. D. Moon
Diabetic Medicine.2015; 32(5): 673. CrossRef - Helicobacter pylori Seropositivity’s Association with Markers of Iron, 1-Carbon Metabolism, and Antioxidant Status among US Adults: A Structural Equations Modeling Approach
May A. Beydoun, Greg A. Dore, Jose A. Canas, Hind A. Beydoun, Alan B. Zonderman, Bradford D. Gessner
PLOS ONE.2015; 10(3): e0121390. CrossRef - Transferrin saturation ratio: a method to estimate risk of cardiovascular mortality in the general population?
Austin G Stack, Waleed Mohamed, Mohamed Elsayed
Biomarkers in Medicine.2014; 8(7): 913. CrossRef - Prediabetes, elevated iron and all-cause mortality: a cohort study
Arch G Mainous, Rebecca J Tanner, Thomas D Coates, Richard Baker
BMJ Open.2014; 4(12): e006491. CrossRef - Dietary Iron Intake and Body Iron Stores Are Associated with Risk of Coronary Heart Disease in a Meta-Analysis of Prospective Cohort Studies
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The Journal of Nutrition.2014; 144(3): 359. CrossRef - Iron: Protector or Risk Factor for Cardiovascular Disease? Still Controversial
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Nutrients.2013; 5(7): 2384. CrossRef - Non-Hfe Iron Overload: Is Phlebotomy the Answer?
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PLoS ONE.2013; 8(9): e72911. CrossRef
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